Friday Pearl

Healthy Aging

Friday, February 02, 2018

Nutrition has important long-term consequences for health and aging that affect gene expression, as does calorie restriction. Therefore, it's vitally important to consume nutrient-dense calories and leave those high-calorie, nutrient-lacking junk foods on the supermarket and convenience store shelf.


Something as simple and cost-effective as reasonable caloric restriction is proving to be powerful protection for the aging heart and vasculature. Vast amounts of research suggest that type 2 diabetes, abdominal obesity, hypertension, and inflammation can be prevented and even reversed with the implementation of lower calorie, but more nutrient-dense diets and regular exercise.


Genomic research suggests exciting possibilities for a dynamic era of scientific investigation based on understanding the effects of nutrients in molecular-level processes in the body.


One of the most frequently-published nutrition science researchers, Bruce Ames, PhD, former Biochemistry / Molecular Biology Department Chair at UC--Berkeley, member of the National Academy of Sciences, and Senior Scientist at Children's Hospital Oakland Research Institute (CHORI), maintains that long-term deficiencies in any one of the more than 40 micronutrients required by the body can cause DNA damage and premature aging.


Nutrient-deficiency diseases represent the major challenge to public health in the 21st century. They are reported to cause 70 percent of deaths and disabilities worldwide.


The onset of most age-related degenerative diseases, are often insidious, without symptoms that would alert the patient or clinician. The estimated nine- to 12-year delay in diagnosis of these diseases is of particular concern because victims lose the opportunity to control the disease process by switching on or off nutrient-dependent genes that are now clinically suggested to control the chronic degenerative disease process.


Thanks to the completion of the genome project, nutrition and health research is finally focused on the prevention of disease by optimizing and maintaining cellular, tissue, organ, and whole-body homeostasis.


This requires better understanding and ultimately regulating a multitude of nutrient-related interactions at the gene, protein, and metabolic levels, including the science and application of human transcriptomics (the study of RNA molecules and the validity of the DNA messages they send), proteomics (the study of an  entire set of proteins expressed by a specific genome, cell, tissue, or organism at a certain time under defined conditions), and metabolomics  (the scientific study of chemical processes involving metabolites).


These complex and exciting disciplines and their technologies are changing the paradigms of health and aging research.


Ellen Troyer, with Spencer Thornton, MD, David Amess and the Biosyntrx staff 




Currently the best defense we have against insidious chronic degeneration is making healthy lifestyle choices that include eating clean, nutrient-dense foods, eliminating empty-calorie junk food, getting enough exercise and sleep, and giving and receiving love. 



Oxidants, antioxidants, and the degenerative diseases of aging. Ames, BN, Shigenaga MK, Hagen TM. Proceedings of the National Academy of Sciences USA (PNAS). September 1993 1; 90(17): 7815-7922 [abstract]

University of California at Davis Nutrigenomics Department

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