Nature, Nurture & Epigenomes
Friday, July 26, 2013
This type of gene expression is controlled by cells called epigenomes that sit outside and on top of the genome. Each individual epigenetic structure tells our genes to switch on or off; to scream DNA/RNA messages, or to whisper them softly. The science term for this signaling effect is called transcription.
After sequencing the human genome, it became clear that genetic information alone was not enough to understand observable characteristics or traits (phenotypes) and it's also becoming clear that epigenetic mechanisms are associated with disease.
Epigenetic science shows that DNA-associated regulatory proteins and RNAs, together with chemical modifications of the DNA itself, determine which parts of the DNA chain are transcribed or silent in a given phase of a cell’s life.
Ellen Troyer, MT MA
A safe and most unfortunate prediction, based on sound science, would be that nutrient-deficient, high-calorie junk-food-related disease linked to current Western society obesity trends will affect future generations' state of health, and add enormous health care cost burden. It's within our power to change this by not voting for those who are funded by monopolistic industries who tempt elected officials to make profit-before-health decisions where our environment, food supply and nutrition is concerned.
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Interplay of early-life nutritioal programming on obesity, inflammation and epigenetic outcomes, Martinez JA, Cordfero P, et al. Proc Nutr Soc. 2012 May; 71(2). 276-83, [abstract]
Impact on Nutritional Epigenomics on Disease Risk and Prevention: Introduction. Ong TP, Perusse L. Nutrigenetics and Nutrigenomics. [full text]
Darwin's passionate environmentalism or the dangerous fallacy of the 'All-sufficency of natural selection' theory. Marsh D. Nutr Health. 2012 Jan 21(1): 76-90 [abstract]
Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls. Coppede F, Tannorelia P, et al. Antioxidants & Redox Singnaling. 2012 17 (2) [abstract]