Friday Pearl

Thioctic Acid

Friday, October 05, 2018

Thioctic acid is an organosulfur compound derived from caprylic acid, also know as lipoic acid (LA), or alpha-lipoic acid (ALA).

Itís produced in animals and is essential for aerobic metabolism. It's present in almost all foods, but slightly more so in kidney, heart, and liver.

LA is now referred to as the universal antioxidant because itís both water and lipid soluble, making it able to protect both aqueous-based and fat-based areas of body tissues. It's able to act both inside the cells and in the spaces located between cells, often referred to as intercellular spaces.

We were beyond intrigued with the impressive results from a well-tolerated phase II lipoic acid-based, proof-of-concept eye drop study that found an improvement in lens elasticity and near vision. It could prove to be great news for all the mid-40 folks whose arms have suddenly become too short.

Studies in several different systems have demonstrated significant antioxidant properties of LA. It has been shown to quench hydroxyl radicals, singlet oxygen, and hydrogen peroxide, which are all associated with mid-life and older ocular structure / function changes.

LA also has the ability to modify gene expression by stabilizing the DNA protein complex transcription factor known as nuclear factor-kappa B (NFkB).

A previous in-vitro study investigated whether treatment of cultured human retinal pigment epithelium (RPE) cells with LA can protect against oxidative injury and cell death. The results suggest that LA protected these cells against oxidative stress, as measured by cell viability, mitochondrial function, apoptosis, and intracellular glutathione stability.

Further experiments indicate that mitochondria-targeted antioxidants such as lipoic acid may be an effective strategy for reducing or preventing chronic oxidant-induced RPE degeneration in vivo from a variety of sources, including cigarette smoke.

Tracking lipoic acid research may prove to be important to those who suffer from age-related eye or brain structure / function degeneration issues.

It was recognized as the universal antioxidant in 1988.
Ellen Troyer, with Spencer Thornton, MD, David Amess and the Biosyntrx staff



To sum it up; Thioctic Acid, better known as lipoic acid (LA), is a powerhouse sulfur-containing, fatty acid antioxidant, found in every cell of the body. It helps to generate energy that keeps us alive and functioning, as well as regenerating both vitamins C and E. It's also proving to be a key player in glucose metabolism, as well as both a fat and water soluble antioxidant.