BioTears

Support for Dry Eyes

  • Invented by a women-led science team passionately determined to support ocular surface health
  • Biochemically balanced natural ingredients that support  fatty acid metabolism. 
  • Millions of doses safely used by satisfied repeat customers
  • Manufactured to FDA Good Manufacturing Practice standards.
  • 60-day full money back guarantee
  • You have nothing to lose but your dry eyes. 
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BioTears First - the healthy tear film standard of care.

Designed by a woman-led research team that opened the doors for dry eye nutritional therapy in 1998. BioTears systemically address the structure / function cause and effects of dry eyes and is  methodically redesigned when sufficient nutrition science dictates. It is made in a NSF, GMP registered facility. 

It's suggested in peer-reviewed literature that these specific nutrients support normal structure / function production of lubricants in other affected parts of the body, such as mucous membranes of the mouth and vagina, and interior body surfaces such as joints and synovial membranes.

We recommend you scroll up and visit the BioTears Ingredient Scientific Rationale link for more information. The manufacturing link is at the bottom of every page.

Recommended dosage: Four oral capsules per-day; two with each morning and evening meal.

Precautions: Coumadin patients should consult their primary care physician when taking this formulation. Pregnant or lactating women, or individuals with medical conditions should also consult a physician before using.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, or treat any disease.

Dry Eye Overview

Dry eye is the most frequent patient complaint to eye doctors. Lack of successful treatment is the primary reason patients change eye doctors.
 
On Living With Dry Eyes: From the English teacher's blog

Who threw the sand in my face?
What streetfight
Was I in last night?
I remember a book
 
I am waiting for the forty-four days of rain.
I am waiting for my trial in the desert to end.
Who gave the nameless their names?

Pathology of the three-layer tear film:

The Mucus Layer - the closest layer to the corneal epithelium. It is produced by the conjunctival goblet cells, and is absorbed by the corneal surface glycoproteins, creating a hydrophilic surface. Mucin deficiency, or mucopolysaccharide abnormalities, can lead to poor wetting or glycation of the corneal surface with subsequent desiccation and epithelial damage, even in the presence of adequate aqueous tear production.

The Aqueous Layer - the layer between the mucous and lipid layers. It is secreted by the lacrimal gland and incorporates all water-soluble components of the tear film. It also comprises 90% of the tear thickness. The aqueous layer provides moisture and supplies oxygen and important nutrients to the cornea.

The Lipid Layer - the most superficial layer. It is produced by the Meibomiam glands with contributions from the glands of Zeis and Moll of the eye lids. The secretion is an oily material, which is fluid at body temperature and retards evaporation of the aqueous layer and lowers surface tension, thereby allowing the tear-film to adhere to the eye's surface. Androgen receptors are located in both the lacrimal and meibomian glands. A decrease in circulating androgen hormones can result in loss of the oil laye, exacerbating the evaporative tear loss.

The Blink Reflex renews the tear film by delivering aqueous and lipid to the tear film and sweeping away debris. The normal blink interval is about 5 seconds under normal conditions. The tear film is typically stable for about 10 seconds. Tears are normally evaporated or forced out through the nasolacrimal ducts in the inner corner of the eyes on blinking.

The Root Causes of Dry Eyes

Many different things cause dry eyes. The normal aging of tear glands, as well as extended use of contact lens, environmental pollutants, prescription drugs, refractive surgery, nutrient deficiencies and other issues can cause disruption in the tear production and retention process.

Symptoms:

The typical symptoms of the dry eyes include dryness, grittiness, irritation, difficulty reading for long periods of time, burning and even the apparent contradiction of excessive tearing or watering. In extreme cases of dry eye, patients may become unusually sensitive to light, experience severe eye pain, and start to notice diminished vision. Successful treatment may be needed to avoid permanent damage.

Blepharitis can often cause dry eye symptoms due to inflammation of the eyelid margins, which is caused by a bacterial infection (Staphylococci). This condition can compromise the quality of the tear film causing tears to evaporate more quickly. The bacteria produce waste material that can cause a mild toxic reaction leading to chronic red, irritated eyes.

Extended Contact Lens Wear can result in dry eye from corneal oxygen and nutrient deficiency. Protein build-up on contact lens can produce a breeding ground for bacterial growth and surface roughness, further contributing to inflammatory changes. Some contact lens solutions contain preservatives that can also cause chemical irritation of the corneal surface and result in dry eye symptoms.

LASIK Surgery temporarily disrupts the ocular surface/lacrimal gland unit. Also, during LASIK, roughly 60-70% of the superficial nerve fibers in the cornea are severed, which reduces sensation and affects aqueous tear production and delays wound healing. With compromised sensation, the blink rate can slow to the point that the tear film breaks up before the next blink can reconstitute. Though this condition usually clears up after a few months, it may result in mild to severe dry eye syndrome for several months after surgery.

Age - Dry eyes are common in  75% of people over age 65. Tear volume decreases from age 18 as much as 60% by age 65.

Hormonal changes cause decreased tear production brought on by pregnancy, lactation, menstruation, and menopause.

Computer Use causes most people to blink less frequently (about 7 times per minute vs. a normal rate of around 22 times/minute). This leads to increased evaporation along with the fatigue and eye-strain associated with staring at a computer monitor. Any task requiring a great deal of concentration can result in decreased blink rate.

The conventional treatment for dry eyes is to treat the symptoms not the cause:

Artificial Tears: Some form of over-the-counter artificial tears is usually recommended. Although they may provide temporary relief, they merely palliate the symptoms. Worse, the preservatives can aggravate the condition, and can even kill corneal cells. Tears that promise 'get the red out'

Punctal Occlusion: Punctal occlusion is a procedure used to help dry eye patients by closing the tear drainage canals with silicone plugs, which keep most of the fluid from leaving the surface of the eye. This may provide long-term relief.

BioTears Ingredient Rationale

Artificial tears flush out debris, dilute substances trapped in the tear film, and increase tear clearance. They do not, however, support all the factors critical for the maintenance and repair of the ocular surface, nor do they address tear film structure and function or the supporting role it plays in visual acuity.

Oral administration of specific omega 6 essential fatty acids that contain sufficient amounts of gamma-linolenic-acid (GLA) support ocular surface and tear film health. We use Black Currant Seed Oil as our source of omega 6 GLA because it is more stable than either Borage Oil or Evening Primrose Oil. We do not use Flax Seed Oil because it is the most unstable of the essential fatty acid oils, and the small amount of Omega-6 fatty acids it includes does not easily convert to gamma linolenic acid (GLA). 

The nutrient co-factors included in BioTears Oral Gel Caps support normal production of lubricants in the eyes and other affected parts of the body, such as mucous membranes of the mouth and vagina, and interior body surfaces such as joints and synovial membranes. (4)

In developing a tear-specific formula for oral administration, Biosyntrx included the nutrient co-factors that support structure / function of lubricant production by physiologic rather than pharmacological means. These nutrient ingredients are designed to work synergistically rather than individually. 

Mechanism of Action:

Omega 6 fatty acids are suggested to metabolize to the site-specific anti-inflammatory ecosinoid, prostaglandin E1 (PGE1).

Omega 6 fatty acids convert to PGE1 via the linoleic-acid (LA) to gamma-linolenic-acid (GLA) to dihomo-gamma-linolenic-acid (DGLA) to the series one prostaglandins (PGE1). To help ensure this conversion, we included the nutrient co-factors, vitamins A, C, B6, and magnesium. The delta-six-desaturase (D6D) enzyme necessary for this conversion is too easily disrupted by alcohol, aging, smoking, elevated cholesterol levels, and environmental factors without these additional nutrient co-factors, which are also suggested to modulate healthy goblet cell production and neurotransmitter blink response.



Pharmaceutical grade cod liver oil, as a source of Omega 3 EPA/DHA is germane to the formulation. It serves as a health-promoting metabolic gateway boost to the downstream conversion of the Omega 3 to the anti-inflammatory PGE3.

Vitamin E, specifically gamma tocopherols, stabilizes the EFAs.

Curcumin is suggested in peer-reviewed literature to support health by appropriately blocking Omega 6 and Omega 3 fatty acids from metabolizing to the series 2 prostaglandins.

Vitamin C, as ascorbic acid and fat-soluble absorbyl palmitate,supports prostaglandin (PGE1) synthesis due to the extended half-life of the fat-soluble vitamin C over water-soluble ascorbic acid. This Vitamin C combination supports the healthy production of IgE concentrates in tears, the first line of basophil and mast cell defense against invading pathogens and allergens.

Lactoferrin  supports structure / function levels of iron binding proteins that support inhibition of viral and bacterial infections, as well as supporting  balance other tear lipocalins (family of proteins that transport small hydrophobic molecules), which support modulation of the surface tension of the tear film, which can affect the ocular surface comfort of the contact lens wearer. Lactoferrin taken orally appears to survive absorption in the stomach by converting to a very small molecule called lactoferricin which can easily find its way into secretory tissue including the eyes.

Background: Lactoferrin is produced in the tear film by neutrophils that constitute the "first line of defense" against infection. Neutrophil apoptosis (programmed cell death) signals the macrophage to clean up debris from wound sites, including surgically induced wounds (LASIK).

Green Tea is included to support osmolarity modulation.
 
BioTears Oral GelCaps are designed to help support inhibition of the LASIK induced dry eye by supporting post-surgical wound healing response, enhancing lacrimal and meibomian gland output, as well as supporting the post-op acetylcholine neurotransmitter blink response. 

Bibliography

  • Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. Barabino S, Rolando M, Camicione P, Ravera G, Zanardi S, Giuffrida S, Calabria G. Cornea. 2003 Mar;22(2):97-10 [abstract 

  • Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects. Wu D, Meydani M, Leka LS, Nightingale Z, Handelman GJ, Blumberg JB, Meydani SN. American Journal of Clinical Nutr. 1999 Cot;70(4):536-43. [abstract]

  • Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. Johnson MM, Swan DD, Surette ME, Stegner J, Chilton T, Fonteh AN, Chilton FH. J Nutr. 1997 Aug;127(8):1435-44. [abstract 

  • Sjogren's syndrome and the sicca syndrome: the role of prostaglandin E1 deficiency. Treatment with essential fatty acids and vitamin C. Horrobin DF, Campbell A. Med Hypotheses 1980 Mar;6(3):225-32 [abstract]

  • The immunoregulatory role of vitamins A, D and E in patients with primary Sjogren's syndrome. Szodoray P, Hovath IF, et al. Rheumatology 2009 Nov 27 [abstract]

  • A compositional based model for the tear film layer. McCulley JP, Shine W. Trans Am Ophthalmol Soc. 1997;95:79-88; discussion 88-93. [abstract 

  • Impact of antiandrogen treatment on the fatty acid profile of neutral lipids in human meibomian gland secretions. Sullivan BD, Evans JE, Krenzer KL, Reza Dana M, Sullivan DA J Clin Endocrinol Metab. 2000 Dec;85(12):4866-73. [abstract 

  • Identification by gas chromatography/mass spectrometry of long-chain fatty acids and alcohols from hamster meibomian glands using picolinyl and nicotinate derivatives. Harvey DJ. Biomed Chromatogr. 1989 Nov;3(6):251-4 [abstract]

      
  • Vitamin E prevents changes in the cornea and conjunctiva due to vitamin A deficiency. Fujikawa A, Gong H, Amemiya T. Graefes Arch Clin Exp Ophthalmol. 2003 Apr;241(4):287-97. [abstract 

  • Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Tei M, Spun-Michaid SJ, et al. Invest Ophthalmol Vis Sci. 2000 Jan;41(1):82-8. [abstract 

  • Lacrimal gland uptake and metabolism of ascorbic acid. Dreyer R, Rose RC. Proc Soc Exp Biol Med. 1993 Feb;202(2):212-6. [abstract]

      
  • Relationship between goblet cell density and tear function tests. Yeo AC, Carkeet A, Carney LG, Yap MK. Ophthalmic Physiol Opt. 2003 Jan;23(1):87-94. [abstract 

  • Pro- and Anti-inflammatory Forms of Interleukin-1 in the Tear Fluid and Conjunctiva of Patients with Dry-Eye Disease Abraham Solomon, Dilek Dursun, Zuguo Liu, Yuhuan Xie, Angelo Macri and Stephen C. Pflugfelder. Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2283-92. [abstract 

  • Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH. J Nutr. 2000 Aug;130(8):1925-31. [abstract 

  • Gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells Jiang Q, Elson-Schwab, Courtemanche C, Ames BN Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11494-9. [abstract]

      
  • Safety and Anti-Inflammatory Activity of Curcumin: A Component of Turmeric (Curcuma longa). Chainani-Wu N. Altern Complement Med 2003 Feb;9 (1): 161-8 [abstract]

     
  • Pseudokeratoconus caused by rosacea. Dursun D, Piniella AM, Pflugfelder SC. Cornea 2001 Aug;20(6):668-9 [abstract]

      
  • Tear lipocalins: potential lipid scavengers for the corneal surface. Glasgow BJ, Marshall G, Gasymov OK, Abduragimov AR, Yusifov TN, Knobler CM Invest Ophthalmol Vis Sci 1999 Dec;40(13):3100-7 [abstract 

  • The inhibition of mast cell activation by neutrophil lactoferrin: uptake by mast cells and interaction with tryptase, chymase and cathepsin G. HeS, McEven AR, blewell SA. Biochem Pharmacol 2003 Mar 15; 65 (6): 1007-15 [abstract]

      
  • Components responsible for the surface tension of human tears. Nagyova B, Tiffany JM. Curr Eye Res 1999 Jul;19(1):4-11 [abstract]

      
  • Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NFkappa B. Haversend L, Ohlsson BG, Hahn-Sone M. et al. Cell Immunol. 2002 Dec; 220 (2); 83-95 [abstract 

  • Bovine lactoferrin stimulates the phagocytic activity of human neutrophils: identification of its active domain. Miyacchi H, Hashimoto S, et al. Cell Immunol. 1998 Jul 10;187(1):34-7. [abstract 

  • What is dry eye and what does it mean to the contact lens wearer? Foulks, GN. Eye Contact Lens. 2003 Jan;29(1 Suppl):S96-100; discussion S115-8, S192-4. [abstract]

      
  • A multi-centre study of lapsed contact lens wearers. Ophthalmic Physiol Opt. 2002 Nov;22(6):516-27. [abstract]

      
  • Lipid, lipase and lipocalin differences between tolerant and intolerant contact lens wearers. Glassom M, Stapleton F. Willcox M Curr Eye Res. 2002 Oct; 25 (4); 227-35 [abstract 

  • Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. Macri A, Giuffrida S, et al. Graefes Arch Clin Exp Ophthalmol. 2003 May 27 [epub ahead of print] [abstract]

  • Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells. Cavet M, Harrington K, et al. Molecular Vision 2011: 17:533-542 [abstract]

  • Influence of corneal refractive surgery on the lacrymal film. Pisella PJ, Godon C, Auzerie O, Baudouin C. Fr Ophtalmol 2002 Apr;25(4):416-22 [abstract 

  • Diagnosis and therapy of LASIK-induced neurotrophic epitheliopathy. Breil P, Frisch L, Dick HB. Ophthalmologe 2002 Jan;99(1):53-7 [abstract 

  • Dry eye after refractive surgery. Ang RT, Dartt DA, Tsubota K. Curr Opin Ophthalmol 2001 Aug;12(4):318-22 [abstract]