Oculair Product Information

Oculair is a potent full-spectrum multiple vitamin/mineral/antioxidant dietary supplement that supports the normal aging process. It is designed to support the micronutrient needs of the Generation X and older patient  It reflect the most recent peer-reviewed nutrition science.

Oculair is a four capsules-per-day formulation designed to protect the entire body including the eyes, from the damaging effects of age-related oxidative stress and free radicals, which are suggested to be responsible for the progression of all chronic degenerative diseases. Leading experts agree that maintaining a consistent level of a well-designed  combination of organ-specific antioxidant free radical scavengers best protects our bodies and eyes and slows the aging process symptoms. 

Oculair contains efficacious amounts of the full-spectrum of nutrients suggested to neutralize singlet oxygen and super oxide free radicals that damage the vascular system and the macula.

Oculair addresses the universal need to keep homocysteine levels in check by including efficacious amounts of vitamin B6, B12 and Folic Acid.

A large number of thought-leading ophthalmologist and optometris recommend Oculair to their entire patient base, including their AMD patients because this cost-effective full-spectrum formulation contains all the nutrients used in the ARED study and the Lutein Antioxidant Supplement Trial (LAST) at levels that are considered safe for long-term consumption. Oculair includes 12 mg of FloraGlo lutein and 3 mg of natural zeaxanthin from peppers. Recent science suggests that the central macula may have a preference for zeaxanthin over lutein. Oculair is safe for smokers and former smokers. The Vitamin A included in Oculair is natural retinyl palmitate.  Oculair includes no beta carotene, which insures better lutein and zeaxanthin absorption. 

We recommend you scroll up and visit the Oculair Scientific Rationale link for more information. The Biosyntrx manufacturing link can be found at the bottom of every page.

Oculair can effectively be recommended as a less-potent 2-per-day formulation to the cost-conscious consumer, which still makes it a far more complete formulation than Centrum or Ocuvite at a similar price point.

If purchased individually, it would be necessary to take forty capsules a day and to spend over $150.00 a month to equal the active ingredient micronutrients included in four capsules of Oculair. The cost of Oculair is less than one quarter this amount.

Recommended dosage: For full 4-per-day recommended potency, take 2 capsules with each morning and evening meal.

Precautions: This formulation contains 200 IUs of natural Vitamin E from mixed tocopherols and may be contraindicated for patients with diagnosed retinitis pigmentosa.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, or treat any disease.

Oculair Condition Overview

Unfortunately, too many people wait until they are well past middle age to start thinking about slowing down the aging process. The Biosyntrx science team strongly recommends lifestyle evaluation between 40 and 45 years of age.  This is the age when we are genetically designed to start noticing a few subtle changes that include needing longer arms to read, a few extra pounds, and a bit less energy.

For those who are willing to make appropriate life changes to ensure health, a full and active life does not need to start slipping away at age fifty. Every year of your life should and can be your very best.

An armed brigade of synergistic antioxidant special-forces is more than capable of protecting our eyes and bodies, as well as providing intracellular toxic clean up from previous years of free radical assault, thus drastically slowing the progression of most chronic degenerative diseases.

Free radicals are highly reactive molecules that ravage the innards of cells. Free refers to the fact that these compounds are misfits, with no proper place in cellular society. Radical is the name biochemists give to an atom or molecule with an unpaired electron. Unattached free radicals bond indiscriminately with other molecules, stripping them of electrons with disastrous results, broken chromosomes, crippled enzymes, and punctured membranes. The electron-stripping process is called oxidation, and in controlled circumstances it's a vital part of ordinary cellular metabolism. In the mid-1950s, Denham Harman, a physician and chemist in the Donner Laboratory of medical physics at Berkeley, proposed that the cumulative damage wreaked by free radicals was largely responsible for the aging process. Today his free-radical theory is the most widely accepted model of aging.

Oculair Scientific Rationale

A number of studies have been published in recent peer reviewed journals suggesting those people who take a well formulated daily multiple vitamin/mineral/antioxidant supplement are far healthier than those people who do not take multiples. Individual nutrient supplements need to be balanced with the appropriate spectrum of vitamins and minerals. A well designed full-spectrum supplement can slow the progression of most all chronic degenerative diseases, including those of the eye.^(1-10)

Vitamin A at 2,500 IU is from natural retinyl palmitate. Vitamin A is necessary for night vision, wound healing, and proper immune system function. ^{(11 -12)} Three published studies now link excessive amounts of Vitamin A as retinol to hip fracture in older people. Oculair Vitamin A does not exceed the Institute of Medicines' current recommendation for daily consumption. It is perfectly balanced with Vitamin D.^(13-15)

The B Complex of vitamins B1, B2, B3, B5, B6, B12, Folic Acid, Biotin and Choline are perfectly balanced. Oculair includes the Vitamin B12 (methylcobalamin) because it has proven to be almost as absorptive as the injectable type of vitamin B12. Oculair provides biochemically balanced amounts of folic acid, B6 and B12 to maintain proper homocysteine levels in the average person. ^(16-21)

Vitamin C at 500 mg is a balanced combination of both water-soluble and fat-soluble active ingredient to ensure a constant supply of circulating vitamin C (ascorbyl palmitate). The fat-soluble C esters constantly regenerate other antioxidant vitamins at the cellular level. ^(22-23)

Vitamin D at 1,200 IU is necessary to properly balance Vitamin A and to prevent bone loss. There is literature that now suggests a possible approaching epidemic of vitamin D deficiency due to potent use of sun screen and decreased dairy consumption in the younger consumer, and lack of out-door activity in the older patient.^(24-27)

Vitamin E at 200 IU is a balanced combination of antioxidant natural d-alpha tocopherol, and anti-inflammatory mixed tocopherols, including anti-inflammatory gamma-tocopherol. ⁽²⁸⁾

Full-Spectrum Minerals are perfectly balanced to provide proper bio-electrical responses at the cellular level. This is a major issue for proper enzymatic function in the human body. They include Calcium, Magnesium, Selenium, Boron, Copper, Manganese, Chromium, Vanadium, and Molybdenum, The zinc used in Oculair is chleated with monomethionine. The amino acid methionine is a low molecular weight, binding ligand proven to facilitate absorption and transport of zinc in the human body. This zinc is perfectly balanced with copper and manganese to produce manganese super-oxide dismutase (MnSOD), which is necessary to neutralize singlet oxygen and super oxide free radicals. ^(29-34)

Carotenoids are a scientifically balanced mixture of beta and alpha carotenoids, 1 mg of lycopene, 12 mg of FloraGlo lutein plus 3 mg of natural zeaxanthin from peppers, which strengthen the macula and help prevent certain types of cancers. New science suggests that the central macula has a distinct preference for zeaxanthin.

Excessive amounts of hydrocarbon carotenoids like beta-carotene found in many other eye-care-specific supplement interfere with zanthophill absorption, specifically lutein and zeaxanthin. Excessive beta carotene is also linked to lung cancer and colorectal adenoma in persons who smoke, or did smoke, as well as those use alcohol. ^(35-40)

Phytochemical Antioxidants (anthocyandins - grape seed, bilberry and ginkgo biloba), plus lipoic acid and NAC provide potent antioxidant protection from free radical damage in the entire body and the eyes. ^(41-44)

Bioflavnoids, (hesperidin, quercetin, and rutin) and the amino acid, taurine, strengthen the vascular system, which plays an important role in transporting proper nutrients to every organ in the body including the eye. These nutrients also play a major role in maintaining fluid balance in the eye. ^(45-50)

Carnosine is included to slow the progression of cellular cross-linking which causes cataracts. ⁽⁵¹⁾

Carnitine and Lipoic Acid are included to slow the progression of memory loss and to boost cellular energy. ⁽⁵²⁾

References:

• Accuracy of pharmaceutical advertisements in medical journals.Villanueva P, Peiro S, et al. Lancet. 2003 Jan 4;361(9351):27-32. [abstract]
  
  
• Nutrition supplements and the eye.Brown NA, Bron AJ, et al. Eye 1998;12 (Pt 1):127-33 [abstract]
  
  
• Dark adaptation pattern of pregnant women as an indicator of functional disturbance at acceptable serum vitamin A levels.Wondmikun Y Eur J Clin Nutr 2002 May;56(5):462-68 [abstract]
  
  
• Retinoic acid--a player that rules the game of life and death in neutrophils.Mehta K. Indian J Exp Biol. 2002 Aug;40(8):874-81. [abstract]
  
  
• Serum retinol levels and the risk of fracture.Michaelsson K. Lithell H, et al. N Engl J Med. 2003 Jan 23;348(4):287-94 [abstract]
  
  
• Vitamin A intake and hip fractures among postmenopausal women.Feskanich D, Singh V, et al. JAMA. 2002 Jan 2;287(1):47-54. [abstract]
  
  
• Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture.Melhus H, Michaelsson K, et al. Ann Intern Med. 1998 Nov 15;129(10):770-8. [abstract]
  
  
• Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and the B-vitamins: a facet of nature-nurture interplay.Herrmann, W, Obeid R, et al. Clin Chem Lab Med 2003 Apr;41(4):547-53 [abstract]
  
  
• Hyperhomocysteinemia and vitamin score: correlations with silent brain ischemic lesions and brain atrophy.Polyak Z, Stern F. Dement Geriatr Cogn Disord. 2003;16(1):39-45. [abstract]
  
  
• Betaine supplementation lowers plasma homocysteine in healthy men and women.Steenge GR. Verhoef, P, et al. J Nutr. 2003 May;133(5):1291-5. [abstract]
  
  
• Hyperhomocysteinemia in Japanese patients with convalescent stage ischemic stroke: Effect of combined therapy with folic acid and mecobalamine.Sato Y, Kaji M, et al. J Neurol Sci 2002 Oct 15;202(1-2):65 [abstract]
  
  
• Vitamins for chronic disease prevention in adults: scientific review.Fairfield KM, Fletcher RH. JAMA. 2002 Jun 19;287(23):3116-26. Review. [abstract]
  
  
• Hyperhomocysteinemia and retinal vascular occlusive disease.Abu El-Asrar AM, Addel Gader AG, et al. Eur J Ophthalmol. 2002 Nov-Dec;12(6):495-500. [abstract]
  
  
• Homocysteine as a risk factor for nephropathy and retinopathy in Type 2 diabetes.Looker HC, Fagot-Campagna A Diabetologia. 2003 May 28 [Epub ahead of print] [abstract]
  
  
• Vitamin C is associated with reduced risk of cataract in a Mediterranean population.Valero MP, Fletcher AE, el al. J Nutr 2002 Jun;132(6):1299-306 [abstract]
  
  
• Ascorbic acid spares alpha-tocopherol and decreases lipid peroxidation in neuronal cells.Lix, Huang J, May JM. Biochem Biophys Res Commun 2003 Jun 6;305(3):656-61. [abstract]
  
  
• Vitamin D in preventive medicine: are we ignoring the evidence?Zitterman A Br J Nutr. 2003 May;89(5):552-72. [abstract]
  
  
• Vitamin D and bone health in postmenopausal women.Malabanan AO, Holick MF. J Womens Health 2003 Mar;12(2):151-6. [abstract]
  
  
• Mechanisms by which nutritional disorders cause reduced bone mass in adults.Miller KK. J Womand Health 2003 Mar;12(2):145-50. [abstract]
  
  
• Vitamin D receptor alleles, periodontal disease progression, and tooth loss in the VA dental longitudinal study.Inauaki K, Krall EA, et al. Periodontol. 2003 Feb;74(2):161-7. [abstract]
  
  
• Gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells.Elson-Schwab I, Courtemanche C, Ames BN. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11494 [abstract]
  
  
• Dietary reference values for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium and zinc.Shenkin A. J Hum Nutr Diet 2003 Jun;16(3):199-200. On file in Biosyntrx research office. [abstract]
  
  
• Effect of a complete nutritional supplement on antibody response to influenza vaccine in elderly people.Wouters-Wesseling W. Rozendaal M, J Gerontol. A Biol Sci Med Sci. 2002 Sep;57(9):M563-6. [abstract]
  
  
• Manganese-Based complexes of radical scavengers as neuroprotective agents.Vajragupta O, Boonchoong P, et al. Bioorg Med Chem 2003 May 15;11(10):2329-2337. [abstract]
  
  
• The relationship between serum trace element changes and visual function in heavy smokers.Uz E, Sabin S, Hepsen IF, et al. Acta Ophthalmol Scand 2003 Apr;81(2):161-164. [abstract]
  
  
• Copper control as an antiangiogenic anticancer therapy: lessons from treating Wilson's disease.Brewer GJ. Exp Biol Med (Maywood) 2001 Jul;226(7):665-73 [abstract]
  
  
• Depletion of Intracellular Zinc and Copper with TPEN Results in Apoptosis of Cultured Human Retinal Pigment Epithelial Cells.Hyae Jung Hyun, Joon Hong sohn, et al. Investigative Ophthalmology and Visual Science. 2001;42:460-465. [abstract]
  
  
• Selenium deficiency and viral infection.Beck MA, Levander OA, Handy J. J Nut r 2003 May;133(5 Suppl 1):1463S-7S [abstract]
  
  
• Lutein and Zeaxanthin as Protectors of Lipid Membranes against Oxidative Damage.Agnieszka Sujak, Janna Gabrielska, et al. The Structural Aspects. Biochemistry and Biophysics Vol. 371, No. 2, November 15, 1999 [abstract]
  
  
• Influence of Lutein Supplementation on Macular Pigment, Assessed with Two Objective Techniques.Tos T, Berendschot R, et al. Investigative Ophthalmology and Visual Science. 2000;41:3322-3326. [abstract]
  
  
• Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans.Bone RA, Landrum JT, et al. J Nutr 2003 Apr;133(4):992-8 [abstract]
  
  
• Singlet oxygen quenching by dietary carotenoids in a model membrane environment.Cantrell A, McGarvey DJ, et al. Arch Biochem Biophys 2003 Apr 1;412(1):47-54. [abstract]
  
  
• Effects of 4 y of oral supplementation with beta-carotene on serum concentrations of retinol, tocopherol, and five carotenoids.Nierenberg DW, Dain BJ, et al. Am J Clin Nutr 1997 Aug;66(2):315-9. [abstract]
  
  
• Total antioxidant capacity of human blood plasma from healthy adults.Lipinska S, Goraca A, et al. J Neurochem 2003 Jun;85 [abstract]
  
  
• Neoplastic and Antineoplastic Effects of beta-Carotene on Colorectal Adenoma Recurrence: Results of a Randomized Trial.BARON ja, cOLE bf, ET AL. Natl Cancer Inst 2003 May 21;95(10):717-22. [abstract]
  
  
• Bioavailablility of elderberry anthocyanins.Milbury PE, Cao G, at al Mech Ageing Dev 2002 Apr;123(8):997-1006 [abstract]
  
  
• Pilot study on the clinical effects of dietary supplementation With Enzogenol(R), a flavonoid extract of pine bark and vitamin C.Shand B, Strey C, et al. Phytother Res 2003 May;17(5):490-4 [abstract]
  
  
• Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma.Quaranta L, Bettelli S, et al. Ophthalmology 2003 Feb;110(2):359-62; discussion 362-4. [abstract]
  
  
• Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production.Midaoui AE, Elumade A, et al. Am J Hypertens. 2003 Mar;16(3):173-9. [abstract]
  
  
• Flavonoid intake and risk of chronic diseases.Knekt P, Kumpulainen J, et al. Am J Clin Nutr 2002 Sep;76(3):560-8 [abstract]
  
  
• Antioxidant effect of flavonoids after ascorbate/Fe(2+)-induced oxidative stress in cultured retinal cells.Areias FM, Rego AC, et al. Biochem Pharmacol 2001 Jul 1;62(1):111-8 [abstract]
  
  
• Repair of amino acid radicals of apolipoprotein b100 of low-density lipoproteins by flavonoids. A pulse radiolysis study with quercetin and rutin.Fi;pe P, Moriere P, et al. Biochemistry 2002 Sep 10;41(36):11057-64 [abstract]
  
  
• Treatment with taurine, diltiazem, and vitamin E retards the progressive visual field reduction in retinitis pigmentosa: a 3-year follow-up study.Pasantes-Morales H, Quiroz H, et al. Metab Brain Dis. 2002 Sep;17(3):183-97. [abstract]
  
  
• Influences of taurine and micronutrients on nitric oxide synthase expression and cGMP content in rat retina.Mi MT. Ahu JD, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2000 Nov;16(4):343-6. Chinese. [abstract]
  
  
• The role of diet in cognitive decline.Solfrizzi V, Panza F, et al. J Neural Transm 2003 Jan;110(1):95-110 [abstract]
  
  
• Taurine as a universal carrier of lipid soluble vitamins: a hypothesis.Petrosian AM, Haroutounian JE. Amino Acids. 2000;19(2):409-21. Review. [abstract]
  
  
• N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts.Babizhayev MA, Deyev AI, et al. Peptides 2001 Jun;22(6):979-94 [abstract]
  
  
• The role of carnitine in normal and altered fatty acid metabolism.Hoppel C. Am J Kidney Dis. 2003 Apr;41(4 Suppl 4):S4-S12. [abstract]
  
  
• Use of vitamin supplements and cataract: the Blue Mountains Eye Study.Kuznairz M, Mitchell P, et al. Am J Ophthalmol 2001 Jul;132(1):19-26 [abstract]
  
  
• Current use of dietary supplementation in patients with age-related macular degeneration.Chang, CW, Chu G, et al. Can J Ophthalmol. 2003 Feb;38(1):27-32. [abstract]
  
  
• Nutrition and retinal degenerations.Berson EL. nt Ophthalmol Clin. 2000 Fall;40(4):93-111. Review. [abstract]
  
  
• Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessment.Falsini B, Piccardi M, et al. Ophthalmology. 2003 Jan;110(1):51-60; discussion 61. [abstract]