A Small Edge That Translates to Big Gains

  • 4 mg of zeaxanthin combined with 25 mg of fat soluble vitamin C
  • Supports central macula protection
  • Supports visual and brain structure / function performance during sports.
  • Supports neural tissue  structure / function.
  • 180 capsule count per bottle
  • Recommended dosage: 1 or 2 capsules daily
  • Made in the USA to FDA Good Manufacturing Practice Standards (GMP) and presented in vegetable capsules for maximum absorption.
  • Sold with full money back guarantee
Add to Cart

Zeaxanthin Product Information

Zeaxanthin is one of the two carotenoids contained within the retina. Within the central macula, zeaxanthin is the dominat component. Zeaxanthin-4 includes four mg of Omnixan zeaxanthin with 25 mg of fat soluble ascorbyl palmitate Vitamin C. 
Not all supplemental zeaxanthin is the same. Zeanxanthin-4 is made in a NSF GMP registered facility.
The Omnixan natural zeaxanthin in Biosyntrx Zeaxanthin-4 comes from  paprika peppers grown in the U.S.A. Paprika peppers have a higher concentration of pure zeaxanthin that any other plant source.  Omnixan is a raw ingredient from Kalsec, a premiere supplier of U.S. grown herbs and plant-based nutritionals. The paprika peppers are grown on on a Kalsec owned TX  farm and processed at a Kalsec owned U.S.A  facility.  Zeaxanthin-4 is manufactured in a U.S.A. NSF/GMP facility, as are all Biosyntrx formulations. 

Zeaxanthin Overview

Zeaxanthin is suggested in peer-reviewed literature to be the central macula preference over lutein. Dietary and supplemental Zeaxanthin is preferentially deposited at the center of the macula. If the diet is deficient in zeaxanthin, which most diets are, and supplemental zeaxanthin is not available, the macula preference for zeaxanthin is so strong the body will convert a small amount of dietary lutein to a similar molecule called meso-zeaxanthin in an attempt to supply the eye with pigment that best protects the macula. Meso zeaxanthin is not found anywhere in the body, except in the eye.

Ingredient Rationale for Zeaxanthin-4

From the many carotenoids in the diet, the human retina selectively accumulates only two: zeasanthin and lutein. Their concentration is so high in the macula they are visible as a dark yellow spot called the macular pigment.

Macula pigment density has been implicated as a risk factor in age-related macular degeneration (AMD), the most prevalent cause of vision loss in the elderly. Significantly lower macular pigment levels have been found in people with factors known to increase risk for AMD.

An interesting study was recently presented in an ARVO poster that suggests activation of retinal nuclear factor kappa beta (NFkB), an early event in the development of retinopathies, including diabetes-induced oxidative damage, mitochondrial super oxide and nitrative stress in the retina, may be prevented with supplemental zeaxanthin.

Studies on sports performance have now been done on baseball players and young adults that clearly suggest zeaxanthin, and lutein to a lesser extent supports visual performance in athletics.

A Biosyntrx Editorial on Zeaxanthin and Lutein:

It's important that consumers and eye care professionals become aware that the xanthophyll carotenoids, zeaxanthin and lutein are now being included in formulations (including the AREDs2 formulation) to replace the antioxidant singlet oxygen quenching hydro-carbon carotenoid, beta-carotene. None of the new formulations are including Vitamin A, as retinyl palmitate when they remove the beta-carotene.

Beta-carotene has the ability to convert to retinol, if the vitamin A liver stores are deficient, which they are in many older people. Vitamin A deficiency can be responsible for night driving problems in the older population.

Unfortunately, unlike beta-carotene, zeaxanthin and lutein have almost no ability to convert to Vitamin A retinol, so the science behind the substitution is a bit flawed - since Vitamin A retinol is vital to the health of the retina, specifically the rods and cones.

The best solution: supplement with biochemically balanced amounts of zeaxanthin, lutein, and vitamin A as retinyl palmitate, in a full-spectrum supplement. Additional zeaxanthin or lutein supplementation should be the decision of the consumer and his or her eye care professional.

Carotenoid Cation Formation and the Regulation of Photosynthetic Light Harvesting. Holt, N, Zigmantas D, Valkunas L, et al. Science, Vol 307 Issue 5708, 433-436, January 21, 2005 [abstract]

A randomized placebo-controlled study on the effects of lutein and zeaxanthin on visual processing speed in young healthy subjects.  Bovier ER, Hammond BR. Arch Biochem Biophys. 2014 Dec 4. [abstract]

Influence of the dietary carotenoids lutein and zeaxanthin on visual performance: application to baseball. Hammond DR JR. Fletcher LM. Am J Clin Nutr 2012 Nov;96(5): [abstract]

Long term dietary supplementation with zeaxanthin reduces photoreceptor death in light-damaged Japanese quail. Thomson LR, Toyoda Y, et al. Exp Eye Res. 2002 Nov;75(5):529-42. [abstract]

Xanthophylls and Alpha Tocopherol Decrease UVB-Induced Lipid Peroxidation and Stress Signaling in Human Lens Epithelial Cells. Chitchumroonchokchi CK, Bomser JA, et al. J Nutr, 2004 Dec;134(120:3225-3232 [abstract]

* Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers. Wright ME, Mayne ST, et al. Am J Epidemiol 2004 Jul 1;160(1):68-76 [abstract]